Publication

Papers (representative)

A Dynamic Substrate Pool Revealed by cryo-EM of a Lipid-Preserved Respiratory Supercomplex. Jeon TJ, Lee SG, Yoo SH, Kim M, Song D, Ryu J, Park H, Kim DS, Hyun J, Kim HM, Ryu SE. (2022) Antioxid Redox Signal. doi: 10.1089/ars.2021.0114. Online ahead of print.

Identification of a novel inhibitor of liver cancer cell invasion and proliferation through regulation of Akt and Twist1. Ha J, Lee S, Park J, Seo J, Kang E, Yoon H, Kim BR, Lee HK, Ryu SE, Cho S. Sci Rep. 2021 Aug 18;11(1):16765.

Phospholipid transfer function of PTPIP51 at mitochondria-associated ER membranes. Yeo HK, Park TH, Kim HY, Jang H, Lee J, Hwang GS, Ryu SE, Park SH, Song HK, Ban HS, Yoon HJ, Lee BI. EMBO Rep. 2021 Jun 4;22(6):e51323. doi: 10.15252/embr.202051323. Epub 2021 May 2

BAFF-neutralizing interaction of belimumab related to its therapeutic efficacy for treating systemic lupus erythematosus. Shin W, Lee HT, Lim H, Lee SH, Son JY, Lee JU, Yoo KY, Ryu SE, Rhie J, Lee JY, Heo YS. Nat Commun. 2018 Mar 23;9(1):1200.

Structural and biochemical analysis of atypically low dephosphorylating activity of human dual-specificity phosphatase 28. Ku B, Hong W, Keum CW, Kim M, Ryu H, Jeon D, Shin HC, Kim JH, Kim SJ, Ryu SE. PLoS One. 2017 Nov 9;12(11):e0187701.

Two intermediate states of the conformational switch in dual specificity phosphatase 13a. Wei CH, Min HG, Kim M, Kim GH, Chun HJ, Ryu SE. Pharmacol Res. 2018 Feb;128:211-219.

Structural basis of checkpoint blockade by monoclonal antibodies in cancer immunotherapy. Lee JY, Lee HT, Shin W, Chae J, Choi J, Kim SH, Lim H, Won Heo T, Park KY, Lee YJ, Ryu SE, Son JY, Lee JU, Heo YS. (2016) Nat Commun. 7, 13354

BetaCavityWeb: a webserver for molecular voids and channels. Kim JK, Cho Y, Lee M, Laskowski RA, Ryu SE, Sugihara K, Kim DS. (2015) Nucleic Acids Res. 43(W1),W413-8.

The family-wide structure and function of human dual-specificity protein phosphatases. Jeong DG, Wei CH, Ku B, Jeon TJ, Chien PN, Kim JK, Park SY, Hwang HS, Ryu SY, Park H, Kim DS, Kim SJ, Ryu SE. (2014) Acta Crystallogr D Biol Crystallogr. 70, 421-435.

Broadly neutralizing anti-hepatitis B virus antibody reveals a complementarity determining region H3 lid-opening mechanism. Chi SW, Maeng CY, Kim SJ, Oh MS, Ryu CJ, Kim SJ, Han KH, Hong HJ, Ryu SE. Proc Natl Acad Sci U S A. 2007 May 29;104(22):9230-5.

Redox regulation of OxyR requires specific disulfide bond formation involving a rapid kinetic reaction path. Lee C, Lee SM, Mukhopadhyay P, Kim SJ, Lee SC, Ahn WS, Yu MH, Storz G, Ryu SE. Nat Struct Mol Biol. 2004 Dec;11(12):1179-85.

Structural basis of the redox switch in the OxyR transcription factor. Choi H, Kim S, Mukhopadhyay P, Cho S, Woo J, Storz G, Ryu SE. Cell. 2001 Apr 6;105(1):103-13.

Crystal structure of proteolytic fragments of the redox-sensitive Hsp33 with constitutive chaperone activity. Kim SJ, Jeong DG, Chi SW, Lee JS, Ryu SE. Nat Struct Biol. 2001 May;8(5):459-66.

Crystal structure of a novel human peroxidase enzyme at 2.0 A resolution. Choi HJ, Kang SW, Yang CH, Rhee SG, Ryu SE. Nat Struct Biol. 1998 May;5(5):400-6.

Crystal structure of an HIV-binding recombinant fragment of human CD4. Ryu SE, Kwong PD, Truneh A, Porter TG, Arthos J, Rosenberg M, Dai XP, Xuong NH, Axel R, Sweet RW, Hendrickson, WA. Nature. 1990 Nov 29;348(6300):419-26.

Molecular characteristics of recombinant human CD4 as deduced from polymorphic crystals. Kwong PD, Ryu SE, Hendrickson WA, Axel R, Sweet RM, Folena-Wasserman G, Hensley P, Sweet RW. Proc Natl Acad Sci U S A. 1990 Aug;87(16):6423-7.

Patents (representative)

Ace2 와 CD16/CD3 항체를 양쪽 팔에 갖고 있는 이중특이성 항체와 이의 용도 (한국 출원) 출원번호: 10-2021-0090947, 출원일: 2021.07.12

항 인간 트랜스페린 수용체 항체의 돌연변이체, 및 이를 이용한 이중특이적 항체, 항체-약물 접합체 및 약학 조성물 (한국 출원) 출원번호: 10-2021-0092822, 출원일: 2021.07.15

PTPsigma-Fc 융합단백질과 이의 의약학적 응용 (한국 출원) 출원번호: 10-2021-0117865, 출원일: 2021.09.03

안정화된 Ace2 변이체, 이를 이용한 Ace2-Fc 융합단백질 및 COVID-19 예방 또는 치료용 약학 조성물 (한국 출원) 출원번호: 10-2021-0129658, 출원일: 2021.09.30

Fc 변이체를 포함하는 이종이합체 및 이의 제조방법 (한국 출원) 출원번호: 10-2021-0153428, 출원일: 2021.11.09

IL-2/IL-2Rα Fc 융합단백질, 이의 제조방법 및 이를 포함하는 약학 조성물 (한국 출원) 출원번호: 10-2021-0182903, 출원일: 2021.12.20

PTPSIGMA-FC 융합단백질 및 이를 포함하는 약학 조성물 (PCT 출원) 출원번호: PCT/KR2021/012763, 출원일: 2021.09.17

안정화된 Ace2 변이체, 이를 이용한 Ace2-Fc 융합단백질 및 COVID-19 예방 또는 치료용 약학 조성물 (PCT 출원) 출원번호: PCT/KR2021/013511, 출원일: 2021.10.01

PHARMACEUTICAL COMPOSITION CONTAINING DUSP1 INHIBITOR (미국 등록) 등록번호: 11,147,807 등록일: 2021.10.19

신경손상치료제로서의 티아다이아졸피리미딘, 벤조디옥솔, 이소옥사졸로피리미딘, 피롤리딘디올, 벤조이미다졸로티아졸, 일루달릭산 화합물과 이의 의약학적 응용. 등록번호: 10-1701555, 등록일: 2017.01.24., 권리만료일: 2033.06.20

DUSP1 활성의 알로스테릭 저해 기작을 갖는 화합물과 이의 의약학적 응용. 등록번호: 10-1882790, 등록일: 2018.07.23., 권리만료일: 2037.04.10

ＰＴＰσ매개성 질환 치료 또는 예방용 약학적 조성물. 등록번호: 10-1646725, 등록일: 2016.08.02.

Papers (All)

(2022)

(2021)

Synthesis and Structure-Activity Relationships of Aristoyagonine Derivatives as Brd4 Bromodomain Inhibitors with X-ray Co-Crystal Research. Yoo M, Park TH, Yoo M, Kim Y, Lee JY, Lee KM, Ryu SE, Lee BI, Jung KY, Park CH.Molecules. 2021 Mar 17;26(6):1686.

Purification, crystallization and X-ray crystallographic analysis of RPTPH. Kim M and Ryu SE. (2021) Biodesign 9, 5-58.

Structural mechanism of inhibitor-resistance by ERK2 mutations. Park YS, Kim M, Ryu SE (2021) Biodesign 9, 14-18.

(2020)

Crystal Structure of the Kinase Domain of MerTK in Complex with AZD7762 Provides Clues for Structure-Based Drug Development. Park TH, Bae SH, Bong SM, Ryu SE, Jang H, Lee BI.Int J Mol Sci. 2020 Oct 23;21(21):7878.

Crystal structure of the mouse endonuclease G. Park KH, Yoon SM, Song HN, Yang JH, Ryu SE, Woo EJ.Biochem Biophys Res Commun. 2020 May 21;526(1):35-40.

MGOS: A library for molecular geometry and its operating system. Kim DS, Ryu J, Cho Y, Lee M, Cha J, Song C, Kim SW, Laskowski, RA, Sugihara K, Bhak J, Ryu SE (2020) Comp. Phys. Com. 251, 107101.

A novel allosteric inhibitor of protein tyrosine phosphatase sigma. Kim MR, Kim M, Ryu SE (2020) Biodesign 8, 55-59.

(2019)

Synthesis and biological evaluation of acylthiourea against DUSP1 inhibition. Kim BY, Yoon JH, Kim M, KIm JN, Park HS, Ryu SE, Lee S (2019) Bioorg. Med. Chem. Lett. 29, 1746-1748.

Virtual screening and biochemical evaluation to identify the allosteric inhibitors of dual specificity phosphatase 1. Park H, Kim M, Park TH, Jeon TJ, Chun HJ, Ryu SE (2019) Bull. KOrean Chem. Soc. 40, 236-242.

Crystal structure of the complex of DUSP15 and its inhibitor reveals novel inhibitor binding interactions. Kim M, Ryu H, RyuSE (2019) Biodesign 7, 79-83.

(2018)

Two intermediate states of the conformational switch in dual specificity phosphatase 13a. Wei CH, Min HG, Kim M, Kim GH, Chun HJ, Ryu SE.Pharmacol Res. 2018 Feb;128:211-219.

Crystallization and preliminary diffraction analysis of dual specificity phosphatase 13a. Min HG, Jeon TJ, Wei CH, Kim M, Ryu SE (2018) Biodesign 6, 28-31.

Crystal structure of an activity-enhancing mutant of DUSP19. Ju DG, Jeon TJ, Ryu SE (2018) J. Life Sci. 28, 1140-1146.

Specific binding and catalytic activation of the MAPK-MKP complex. Kim M, Ryu SE (2018) Biodesign 6, 79-83.

(2017)

Molecular mechanism of PD-1/PD-L1 blockade via anti-PD-L1 antibodies atezolizumab and durvalumab.Lee HT, Lee JY, Lim H, Lee SH, Moon YJ, Pyo HJ, Ryu SE, Shin W, Heo YS.Sci Rep. 2017 Jul 17;7(1):5532. doi: 10.1038/s41598-017-06002-8.

Crystallization and preliminary diffraction analysis of DUSP28 through identification of a pseudo-thrombin cleavage site. Hong W, Ku B, Kim M, Kim SJ, Ryu SE (2017) Biodesign 5, 141-144.

(2016)

Identification of novel protein tyrosine phosphatase sigma inhibitors promoting neurite extension. Lee HS, Ku B, Park TH, Park H, Choi JK, Chang KT, Kim CH, Ryu SE, Kim SJ. (2016) Bioorg Med Chem Lett. 26, 87-93.

BetaSCPWeb: side-chain prediction for protein structures using Voronoi diagrams and geometry prioritization. Ryu J, Lee M, Cha J, Laskowski RA, Ryu SE, Kim DS. (2016) Nucleic Acids Res. 44(W1), W416-23.

Structural mobility of the active site in classical protein tyrosine phosphatases and dual specificity phosphatases Wei CH and Ryu SE. (2016) Biodesign 4, 77-87.

(2015)

Structure of the catalytic phosphatase domain of MTMR8: implications for dimerization, membrane association and reversible oxidation. Yoo KY, Son JY, Lee JU, Shin W, Im DW, Kim SJ, Ryu SE*, Heo YS*. (2015) Acta Crystallogr D Biol Crystallogr. 71, 1528-39.

BetaCavityWeb: a webserver for molecular voids and channels. Kim JK, Cho Y, Lee M, Laskowski RA, Ryu SE, Sugihara K, Kim DS. (2015) Nucleic Acids Res. 43(W1),W413-8.

Structural analysis of activity-modulating mutations of DUSP19. Jeon TJ, Nam GT and Ryu SE (2015) Biodesign 3, 111-116.

Enhanced humanization and affinity maturation of neutralizing anti-hepatitis B virus preS1 antibody based on antigen-antibody complex structure. Kim JH, Gripon P, Bouezzedine F, Jeong MS, Chi SW, Ryu SE, Hong HJ. (2015) FEBS Lett. 589, 193-200.

(2014)

Targeting allosteric sites for protein tyrosine phosphatase inhibition. Ryu SE, Kim SJ. (2014) Biodesign 2, 81-90.

Discovery of Novel DUSP4 Inhibitors through the Virtual Screening with Docking Simulations. Park H, Jeon TJ, Chien PN, Park SY, Oh SM, Kim SJ, Ryu SE. (2014) Bull. Korean Chem. Soc 35, 2655-2659.

Discovery of novel DUSP16 phosphatase inhibitors through virtual screening with homology modeled protein structure. Park H, Park SY, Nam SW, Ryu SE. (2014) J. Biomol. Screen 19, 1383-1390.

Crystallization and preliminary X-ray crystallographic analysis of the PH-GRAM domain of human MTMR4. Lee JU, Son JY, Yoo KY, Shin W, Im DW, Kim SJ, Ryu SE, Heo YS. (2014) Acta Crystallogr F Struct Biol Commun. 70, 1280-1283.

Expression, purification, crystallization and preliminary crystallographic analysis of human myotubularin-related protein 3. Son JY, Lee JU, Yoo KY, Shin W, Im DW, Kim SJ, Ryu SE, Heo YS. (2014) Acta Crystallogr F Struct Biol Commun. 70, 1240-1243.

BetaVoid: molecular voids via beta-complexes and Voronoi diagrams. Kim JK, Cho Y, Laskowski RA, Ryu SE, Sugihara K, Kim DS. (2014) Proteins. 82, 1829-1849.

(2013)

Structural basis for the dephosphorylating activity of PTPRQ towards phosphatidylinositide substrates. Yu KR, Kim YJ, Jung SK, Ku B, Park H, Cho SY, Jung H, Chung SJ, Bae KH, Lee SC, Kim BY, Erikson RL, Ryu SE, Kim SJ. (2013) Acta Crystallogr D Biol Crystallogr. 69, 1522-9.

Dual-mode enhancement of metallothionein protein with cell transduction and retention peptide fusion. Lim KS, Lim MH, Won YW, Kim JK, Kang YC, Park EJ, Chae JW, Kim SM, Ryu SE, Pak YK, Kim YH. (2013) J Control Release. 171, 193-200.

Structure of the catalytic domain of protein tyrosine phosphatase sigma in the sulfenic acid form. Jeon TJ, Chien PN, Chun HJ, Ryu SE. (2013) Mol Cells. 36, 55-61.

201Tl heart-liver radioactivity uptake ratio and prediction of decompensation in patients with cirrhosis. Lee MH, Tae HJ, Jun DW, Ryu SE, Choi YY, Kwak MJ, Kang JS (2013) Clin Nucl Med. 38, 169-74.

Identification of potent VHZ phosphatase inhibitors with structure-based virtual screening. Park H, Park SY, Oh JJ, Ryu SE. (2013) J Biomol Screen. 18, 226-31

Protein Tyrosine Phosphatase σ in Proteoglycan-Mediated Neural Regeneration Regulation. Chien PN, Ryu SE. (2013) Mol Neurobiol. 47, 220-7.

Homology modeling and virtual screening approaches to identify potent inhibitors of slingshot phosphatase 1. Park H, Park SY, Ryu SE. (2013) J Mol Graph Model. 39, 65-70.

(2012)

Structure and catalytic mechanism of human protein tyrosine phosphatome. Kim SJ, Ryu SE. BMB Rep. 2012 Dec;45(12):693-9.

Structure-based de novo design of Eya2 phosphatase inhibitors. Park H, Ryu SE, Kim SJ. J Mol Graph Model. 2012 Sep;38:382-8.

Virtual Screening and Biochemical Evaluation of Mitogen-activated Protein Kinase Phosphatase 4 Inhibitors. Park H, Jeon JY, Ryu SE. Bull. Korean Chem. Soc. 2012; 33(11):3772-6.

Identification of Potent VHZ Phosphatase Inhibitors with Structure-Based Virtual Screening. Park H, Park SY, Oh JJ, Ryu SE. J Biomol Screen. 2013 Feb;18(2):226-31.

Discovery of potent inhibitors of receptor protein tyrosine phosphatase sigma through the structure-based virtual screening. Park H, Chien PN, Ryu SE. Bioorg Med Chem Lett. 2012 Oct 15;22(20):6333-7.

Structure and design of broadly-neutralizing antibodies against HIV. Ryu SE, Hendrickson WA. Mol Cells. 2012 Sep;34(3):231-7.

Homophilic interaction of the L1 family of cell adhesion molecules. Wei CH, Ryu SE. Exp Mol Med. 2012 Jul 31;44(7):413-23.

Structural mechanism of disulphide bond-mediated redox switches. Ryu SE. J Biochem. 2012 Jun;151(6):579-88.

Emodin inhibits migration and invasion of DLD-1 (PRL-3) cells via inhibition of PRL-3 phosphatase activity. Han YM, Lee SK, Jeong DG, Ryu SE, Han DC, Kim DK, Kwon BM. Bioorg Med Chem Lett. 2012 Jan 1;22(1):323-6.

Structure-based virtual screening approach to the discovery of novel PTPMT1 phosphatase inhibitors. Park H, Kim SY, Kyung A, Yoon TS, Ryu SE, Jeong DG. Bioorg Med Chem Lett. 2012 Jan 15;22(2):1271-5.

(2011)

Crystal structure of a novel mitogen-activated protein kinase phosphatase, SKRP1. Wei CH, Ryu SY, Jeon YH, Yoon MY, Jeong DG, Kim SJ, Ryu SE. Proteins. 2011 Nov;79(11):3242-6.

Enhanced chondrogenic marker expression of human mesenchymal stem cells by interaction with both TGF-β3 and hyaluronic acid. Bhang SH, Jeon JY, La WG, Seong JY, Hwang JW, Ryu SE, Kim BS. Biotechnol Appl Biochem. 2011 Jul-Aug;58(4):271-6.

Inhibition of Invasion and Capillary-like Tube Formation by Retrohydroxamate-based MMP nhibitors. Choi SS, Ji AR, Yu SW, Cho BH, Park JD, Park JH, Lee HS, Ryu SE, Kim DH, Kang JH, Lee ST. Bull. Korean Chem. Soc. 2011; 32(6):2032-38.

Discovery of Novel Inhibitors of Dual-Specificity Phosphatase Pyst2 with Structure-Based Virtual Screening. Park H, Jeon JY, Ryu SE*, Kim SJ* Bull. Korean Chem. Soc. 2011; 32(7):2167-8.

Identification of novel inhibitors of mitogen-activated protein kinase phosphatase-1 with structure-based virtual screening. Park H, Jeon JY, Kim SY, Jeong DG, Ryu SE. J Comput Aided Mol Des. 2011 May;25(5):469-75.

Structural mechanism of the antigen recognition by the L1 cell adhesion molecule antibody A10-A3. Wei C, Lee EK, Jeon JY, Heo YS, Kim SJ, Heon YH, Kim KH, Hong HJ, Ryu SE. FEBS Lett. 2011 Jan 3;585(1):153-8.

Crystal Structure of Constitutively Monomeric E. coli Hsp33 Mutant with Chaperone Activity. Chi SW, Jeong DG, Woo JR, Lee HS, Park BC, Kim BY, Erikson RL, Ryu SE*, Kim SJ*. FEBS Lett. 2011 Jan 22;585(4):664-70.

Exploring binding sites other than the catalytic core in the crystal structure of the catalytic domain of MKP-4. Jeong DG, Yoon TS, Jung SK, Park BC, Park H, Ryu SE*, Kim SJ*. Acta Crystallogr D Biol Crystallogr. 2011 Jan;67(Pt 1):25-31.

(2010)

Identification of two novel VHR phosphatase inhibitors with structure-based virtual screening. Park H, Jeong JY, Jeong DG, Ryu SE. BKCS. 2010 Dec;31(12):3785-7.

Identification of tyrosine-titrated proteins in HT22 hippocampal cells during glutamate-induced oxidative stress. Yoon SW, Kang S, Ryu SE, Poo H. Cell Prolif. 2010 Dec;43(6):584-93.

Proteomic analysis of oxidative stress-induced neuronal cell death by using two-dimensional fluorescence difference gel electrophoresis. Kim EY, Yoon TS, Bahn YJ, Jeong DG, Park MR, Chung SJ, Park SG, Park BC, Lee SC, Ryu SE, Bae KH. Int J Mol Med. 2010 Dec;26(6):829-35.

Vacuolar (H(+))-ATPases in C. elegans: What can we learn about giant H(+) pumps from tiny worms? Lee SK, Li W, Ryu SE, Rhim T, Ahnn J. Biochim Biophys Acta. 2010 Jul 14.

Use of dimedone-based chemical probes for sulfenic acid detection evaluation of conditions affecting probe incorporation into redox-sensitive proteins. Klomsiri C, Nelson KJ, Bechtold E, Soito L, Johnson LC, Lowther WT, Ryu SE, King SB, Furdui CM, Poole LB. Methods Enzymol. 2010;473:77-94.

Crystal structure of ED-Eya2: insight into dual roles as a protein tyrosine phosphatase and a transcription factor. Jung SK, Jeong DG, Chung SJ, Kim JH, Park BC, Tonks NK, Ryu SE, Kim SJ FASEB J. 2010 Feb;24(2):560-9.

(2009)

Synapse formation regulated by protein tyrosine phosphatase receptor T through interaction with cell adhesion molecules and Fyn. Lim SH, Kwon SK, Lee MK, Moon J, Jeong DG, Park E, Kim SJ, Park BC, Lee SC, Ryu SE, Yu DY, Chung BH, Kim E, Myung PK, Lee JR. EMBO J. 2009 Nov 18;28(22):3564-78.

Broadly neutralizing anti-HBV antibody binds to non-epitope regions of preS1. Chi SW, Kim J, Yi GS, Hong HJ, Ryu SE. FEBS Lett. 2009 Sep 17;583(18):3095-100.

Structure-based de novo design and biochemical evaluation of novel Cdc25 phosphatase inhibitors. Park H, Bahn YJ, Ryu SE. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4330-4.

Crystal structure of the catalytic domain of human MKP-2 reveals a 24-mer assembly. Jeong DG, Jung SK, Yoon TS, Woo EJ, Kim JH, Park BC, Ryu SE, Kim SJ. Proteins. 2009 Aug 15;76(3):763-7.

Purification, crystallization and data collection of the apoptotic nuclease endonuclease G. Yoon SM, Song HN, Yang JH, Lim MY, Chung YJ, Ryu SE, Woo EJ. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 May 1;65(Pt 5):504-7.

Dephosphorylation of the C-terminal tyrosyl residue of the DNA damage-related histone H2A.X is mediated by the protein phosphatase eyes absent. Krishnan N, Jeong DG, Jung SK, Ryu SE, Xiao A, Allis CD, Kim SJ, Tonks NK. J Biol Chem. 2009 Jun 12;284(24):16066-70.

NSC-87877, inhibitor of SHP-1/2 PTPs, inhibits dual-specificity phosphatase 26 (DUSP26). Song M, Park JE, Park SG, Lee do H, Choi HK, Park BC, Ryu SE, Kim JH, Cho S. Biochem Biophys Res Commun. 2009 Apr 17;381(4):491-5.

(2008)

The diversity of lysine-acetylated proteins in Escherichia coli. Yu BJ, Kim JA, Moon JH, Ryu SE, Pan JG. J Microbiol Biotechnol. 2008 Sep;18(9):1529-36.PMID: 18852508 [PubMed - indexed for MEDLINE]Related citations

Identification of novel inhibitors of extracellular signal-regulated kinase 2 based on the structure-based virtual screening. Park H, Bahn YJ, Jeong DG, Woo EJ, Kwon JS, Ryu SE. Bioorg Med Chem Lett. 2008 Oct 15;18(20):5372-6. Epub 2008 Sep 18.PMID: 18835158 [PubMed - indexed for MEDLINE]Related citations

Identification of proteins binding to decursinol by chemical proteomics. Kang HJ, Yoon TS, Jeong DG, Kim Y, Chung JW, Ha JS, Park SS, Ryu SE, Kim S, Bae KH, Chung SJ. J Microbiol Biotechnol. 2008 Aug;18(8):1427-30.

Discovery of novel Cdc25 phosphatase inhibitors with micromolar activity based on the structure-based virtual screening. Park H, Bahn YJ, Jung SK, Jeong DG, Lee SH, Seo I, Yoon TS, Kim SJ, Ryu SE. J Med Chem. 2008 Sep 25;51(18):5533-41.

Monoclonal antibody-based screening assay for factor inhibiting hypoxia-inducible factor inhibitors. Lee SH, Jeong Hee Moon, Eun Ah Cho, Ryu SE, Myung Kyu Lee. J Biomol Screen. 2008 Jul;13(6):494-503.

Discovery of novel PRL-3 inhibitors based on the structure-based virtual screening. Park H, Jung SK, Jeong DG, Ryu SE, Kim SJ. Bioorg Med Chem Lett. 2008 Apr 1;18(7):2250-5.

Discovery of VHR phosphatase inhibitors with micromolar activity based on structure-based virtual screening. Park H, Jung SK, Jeong DG, Ryu SE, Kim SJ. ChemMedChem. 2008 Jun;3(6):877-80.

Structural basis for the cold adaptation of psychrophilic M37 lipase from Photobacterium lipolyticum. Jung SK, Jeong DG, Lee MS, Lee JK, Kim HK, Ryu SE, Park BC, Kim JH, Kim SJ. Proteins. 2008 Apr;71(1):476-84.

(2007)

Structural insight into the constitutive repression function of the nuclear receptor Rev-erbbeta. Woo EJ, Jeong DG, Lim MY, Jun Kim S, Kim KJ, Yoon SM, Park BC, Ryu SE. J Mol Biol. 2007 Oct 26;373(3):735-44.

Phosphoproteomic analysis of neuronal cell death by glutamate-induced oxidative stress. Kang TH, Bae KH, Yu MJ, Kim WK, Hwang HR, Jung H, Lee PY, Kang S, Yoon TS, Park SG, Ryu SE*, Lee SC*. Proteomics. 2007 Aug;7(15):2624-35.

Crystal structure of human slingshot phosphatase 2. Jung SK, Jeong DG, Yoon TS, Kim JH, Ryu SE, Kim SJ. Proteins. 2007 Jul 1;68(1):408-12.

Crystal structure of the major diabetes autoantigen insulinoma-associated protein 2 reveals distinctive immune epitopes. Kim SJ, Jeong DG, Jeong SK, Yoon TS, Ryu SE. Diabetes. 2007 Jan;56(1):41-8.

Crystal structure of the catalytic domain of human DUSP5, a dual specificity MAP kinase protein phosphatase. Jeong DG, Cho YH, Yoon TS, Kim JH, Ryu SE*, Kim SJ*. Proteins. 2007 Jan 1;66(1):253-8.

Crystal structure of human TMDP, a testis-specific dual specificity protein phosphatase: implications for substrate specificity. Kim SJ, Jeong DG, Yoon TS, Son JH, Cho SK, Ryu SE, Kim JH. Proteins. 2007 Jan 1;66(1):239-45.

(2006)

Crystal structure of the catalytic domain of human MAP kinase phosphatase 5: structural insight into constitutively active phosphatase. Jeong DG, Yoon TS, Kim JH, Shim MY, Jung SK, Son JH, Ryu SE*, Kim SJ*. J Mol Biol. 2006 Jul 28;360(5):946-55.

Structure of human DSP18, a member of the dual-specificity protein tyrosine phosphatase family. Jeong DG, Cho YH, Yoon TS, Kim JH, Son JH, Ryu SE, Kim SJ. Acta Crystallogr D Biol Crystallogr. 2006 Jun;62(Pt 6):582-8.

Biflavonoids inhibited phosphatase of regenerating liver-3 (PRL-3). Choi SK, Oh HM, Lee SK, Jeong DG, Ryu SE, Son KH, Han DC, Sung ND, Baek NI, Kwon BM. Nat Prod Res. 2006 Apr;20(4):341-6.

Ganglioside GM3 is involved in neuronal cell death. Sohn H, Kim YS, Kim HT, Kim CH, Cho EW, Kang HY, Kim NS, Kim CH, Ryu SE, Lee JH, Ko JH. FASEB J. 2006 Jun;20(8):1248-50.

Synthesis and biological evaluation of rhodanine derivatives as PRL-3 inhibitors. Ahn JH, Kim SJ, Park WS, Cho SY, Ha JD, Kim SS, Kang SK, Jeong DG, Jung SK, Lee SH, Kim HM, Park SK, Lee KH, Lee CW, Ryu SE, Choi JK. Bioorg Med Chem Lett. 2006 Jun 1;16(11):2996-9.

Protein tyrosine phosphatase 1B inhibitors from Morus root bark. Cui L, Na M, Oh H, Bae EY, Jeong DG, Ryu SE, Kim S, Kim BY, Oh WK, Ahn JS. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1426-9.

(2005)

Crystal structure of the catalytic domain of human VHY, a dual-specificity protein phosphatase. Yoon TS, Jeong DG, Kim JH, Cho YH, Son JH, Lee JW, Ryu SE*, Kim SJ*. Proteins. 2005 Nov 15;61(3):694-7.

PTP1B inhibitory effect of abietane diterpenes isolated from Salvia miltiorrhiza. Han YM, Oh H, Na M, Kim BS, Oh WK, Kim BY, Jeong DG, Ryu SE, Sok DE, Ahn JS. Biol Pharm Bull. 2005 Sep;28(9):1795-7.

Trimeric structure of PRL-1 phosphatase reveals an active enzyme conformation and regulation mechanisms. Jeong DG, Kim SJ, Kim JH, Son JH, Park MR, Lim SM, Yoon TS, Ryu SE. J Mol Biol. 2005 Jan 14;345(2):401-13.

(2004)

Structural basis of cellular redox regulation by human TRP14. Woo JR, Kim SJ, Jeong W, Cho YH, Lee SC, Chung YJ, Rhee SG, Ryu SE. J Biol Chem. 2004 Nov 12;279(46):48120-5.

Positive regulation of apoptosis signal-regulating kinase 1 by hD53L1. Cho S, Ko HM, Kim JM, Lee JA, Park JE, Jang MS, Park SG, Lee DH, Ryu SE, Park BC. J Biol Chem. 2004 Apr 16;279(16):16050-6.

(2003)

Crystal structure of DsbDgamma reveals the mechanism of redox potential shift and substrate specificity(1). Kim JH, Kim SJ, Jeong DG, Son JH, Ryu SE. FEBS Lett. 2003 May 22;543(1-3):164-9.

Origin of the stereospecificity in binding hydroxamates of alpha- and beta-phenylalanine methylamide to thermolysin revealed by the X-ray crystallographic study. Kim SJ, Kim DH, Park JD, Woo JR, Jin Y, Ryu SE. Bioorg Med Chem. 2003 May 29;11(11):2421-6.

The tetrameric structure of Haemophilus influenza hybrid Prx5 reveals interactions between electron donor and acceptor proteins. Kim SJ, Woo JR, Hwang YS, Jeong DG, Shin DH, Kim K, Ryu SE. J Biol Chem. 2003 Mar 21;278(12):10790-8.

Structure of human FIH-1 reveals a unique active site pocket and interaction sites for HIF-1 and von Hippel-Lindau. Lee C, Kim SJ, Jeong DG, Lee SM, Ryu SE. J Biol Chem. 2003 Feb 28;278(9):7558-63.

(2002)

Sulfamide-based inhibitors for carboxypeptidase A. Novel type transition state analogue inhibitors for zinc proteases. Park JD, Kim DH, Kim SJ, Woo JR, Ryu SE. J Med Chem. 2002 Nov 21;45(24):5295-302.

Identification of calmodulin isoform-specific binding peptides from a phage-displayed random 22-mer peptide library. Choi JY, Lee SH, Park CY, Heo WD, Kim JC, Kim MC, Chung WS, Moon BC, Cheong YH, Kim CY, Yoo JH, Koo JC, Ok HM, Chi SW, Ryu SE, Lee SY, Lim CO, Cho MJ. J Biol Chem. 2002 Jun 14;277(24):21630-8.

Novel zinc-binding center and a temperature switch in the Bacillus stearothermophilus L1 lipase. Jeong ST, Kim HK, Kim SJ, Chi SW, Pan JG, Oh TK, Ryu SE. J Biol Chem. 2002 May 10;277(19):17041-7. Epub 2002 Feb 21. Erratum in: J Biol Chem 2002 Jul 12;277(28):25840.

(2001)

Crystallization and preliminary X-ray analysis of a thermoalkalophilic lipase from Bacillus stearothermophilus L1. Jeong ST, Kim HK, Kim SJ, Pan JG, Oh TK, Ryu SE. Acta Crystallogr D Biol Crystallogr. 2001 Sep;57(Pt 9):1300-2.

Binding and regulation of HIF-1alpha by a subunit of the proteasome complex, PSMA7. Cho S, Choi YJ, Kim JM, Jeong ST, Kim JH, Kim SH, Ryu SE. FEBS Lett. 2001 Jun 1;498(1):62-6.

Crystal structure of proteolytic fragments of the redox-sensitive Hsp33 with constitutive chaperone activity. Kim SJ, Jeong DG, Chi SW, Lee JS, Ryu SE. Nat Struct Biol. 2001 May;8(5):459-66.

Structural basis of the redox switch in the OxyR transcription factor. Choi H, Kim S, Mukhopadhyay P, Cho S, Woo J, Storz G, Ryu SE. Cell. 2001 Apr 6;105(1):103-13.

(before 2000)

Effects of metal ions on the activity of protein tyrosine phosphatase VHR: highly potent and reversible oxidative inactivation by Cu2+ ion. Kim JH, Cho H, Ryu SE, Choi MU. Arch Biochem Biophys. 2000 Oct 1;382(1):72-80.

Crystallization and preliminary x-ray crystallographic analysis of NAD+-dependent DNA ligase from Thermus filiformis. Lee JY, Kim HK, Chang C, Eom SH, Hwang KY, Cho Y, Yu YG, Ryu SE, Kwon ST, Suh SW. Acta Crystallogr D Biol Crystallogr. 2000 Mar;56(Pt 3):357-8.

Homology modeling of the receptor binding domain of human thrombopoietin. Song JS, Park H, Hong HJ, Yu MH, Ryu SE. J Comput Aided Mol Des. 1998 Sep;12(5):419-24.

Crystallization and preliminary X-ray studies of hORF6, a novel human antioxidant enzyme. Choi HJ, Kang SW, Yang CH, Rhee SG, Ryu SE. Acta Crystallogr D Biol Crystallogr. 1998 May 1;54(Pt 3):436-7.

Crystal structure of a novel human peroxidase enzyme at 2.0 A resolution. Choi HJ, Kang SW, Yang CH, Rhee SG, Ryu SE. Nat Struct Biol. 1998 May;5(5):400-6.PMID: 9587003 [PubMed - indexed for MEDLINE]Related citations Identification of functionally important residues of human thrombopoietin. Park H, Park SS, Jin EH, Song JS, Ryu SE, Yu MH, Hong HJ. J Biol Chem. 1998 Jan 2;273(1):256-61.

Production of hepatitis B virus preS polypeptide in Escherichia coli by mutation of the 5'-end coding sequence and its purification and characterization. Kim HS, Kim YK, Ryu SE, Hong HJ. Gene. 1996 Oct 24;177(1-2):173-7.

The native strains in the hydrophobic core and flexible reactive loop of a serine protease inhibitor: crystal structure of an uncleaved alpha1-antitrypsin at 2.7 A. Ryu SE, Choi HJ, Kwon KS, Lee KN, Yu MH. Structure. 1996 Oct 15;4(10):1181-92.

Crystallization and preliminary x-ray crystallographic studies of ketosteroid isomerase from Pseudomonas putida biotype B. Oh BH, Kim SW, Ryu SE, Kim SS, Yoon MK, Choi KY. Proteins. 1996 Apr;24(4):514-5.

Structures of an HIV and MHC binding fragment from human CD4 as refined in two crystal lattices. Ryu SE, Truneh A, Sweet RW, Hendrickson WA. Structure. 1994 Jan 15;2(1):59-74.

Structural aspects of CD4 and CD8 involvement in the cellular immune response. Hendrickson WA, Kwong PD, Leahy DJ, Ryu SE, Yamaguchi H, Fleury S, Sékaly RP. Cold Spring Harb Symp Quant Biol. 1992;57:549-56.

Mutational analysis of the interaction between CD4 and class II MHC: class II antigens contact CD4 on a surface opposite the gp120-binding site. Fleury S, Lamarre D, Meloche S, Ryu SE, Cantin C, Hendrickson WA, Sekaly RP. Cell. 1991 Sep 6;66(5):1037-49.

A region in domain 1 of CD4 distinct from the primary gp120 binding site is involved in HIV infection and virus-mediated fusion. Truneh A, Buck D, Cassatt DR, Juszczak R, Kassis S, Ryu SE, Healey D, Sweet R, Sattentau Q. J Biol Chem. 1991 Mar 25;266(9):5942-8.